Methyl 3-oxo-cyclopentane...

Methyl 3-oxo-cyclopentane... - Names and Identifiers

Name	Methyl-3-oxocyclopentane carboxylate
Synonyms	Methyl 3-oxo-cyclopentane... Methyl-3-oxocyclopentane carboxylate Methyl-3-oxo-cyclopentane carboxylate methyl 3-oxocyclopentane-1-carboxylate 1-Methyl-3-oxocyclopentane-1-carboxylate 3-Oxo-cyclopentanecarboxylic acid methyl ester 3-oxo-1-cyclopentanecarboxylic acid methyl ester 3-(Methoxycarbonyl)cyclopentan-1-one, 3-(Methoxycarbonyl)-1-oxocyclopentane
CAS	32811-75-9
InChIKey	KTGCFXSELRVRFH-UHFFFAOYSA-N

Methyl 3-oxo-cyclopentane... - Physico-chemical Properties

Molecular Formula	C7H10O3
Molar Mass	142.15
Density	1.157±0.06 g/cm3(Predicted)
Boling Point	130-140℃ (10 Torr)
Storage Condition	Keep in dark place,Sealed in dry,Room Temperature
Refractive Index	1.4565 (589.3 nm 23℃

Methyl 3-oxo-cyclopentane... - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	R22 - Harmful if swallowed R41 - Risk of serious damage to eyes R52 - Harmful to aquatic organisms
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection.
UN IDs	UN 3082 9 / PGIII
WGK Germany	3
Hazard Class	9
Packing Group	Ⅲ

Methyl 3-oxo-cyclopentane... - Reference Information

Use

methyl 3-oxocyclopenecarboxylate can be used as a pharmaceutical synthesis intermediate, it can be prepared from 3-oxocyclopentanecarboxylic acid as a raw material, and can be used for the synthesis of 3-hydroxycyclopentanecarboxylate, and further can be used for the synthesis of a series of heterocyclic compounds with glutaminase inhibitory activity.
methyl 3-oxocyclopenecarboxylate can be used as a pharmaceutical synthesis intermediate, and can be used for the synthesis of 3-hydroxycyclopentane formate.

preparation method

methyl 3-oxocyclopenecarboxylate: 3-oxocyclopentane carboxylic acid (5.0g, to a solution of 39.1mmol) in methanol (50ml) was added dropwise a catalytic amount of concentrated sulfuric acid (10 drops). After a reaction time of 1 hour at 80 °c, the reaction mixture was cooled to room temperature. The solvent was removed by concentration under reduced pressure, a small amount of water was added to the resulting residue, the pH was adjusted to 8 with a saturated aqueous sodium hydrogen carbonate solution, and then extracted with ethyl acetate (30ml x 3 times). The organic phases were combined, dried, and concentrated to give the title compound methyl 3-oxocyclopentanoate (4.5g,81%).

Last Update：2024-04-09 21:04:16